Respiratory depression, especially in the presence of cyanosis and excessive bronchial secretion, and after operation on biliary tract, acute alcoholism, head injuries and conditions in which intracranial pressure is raised, hypotension, asthma, hepatic impairment, during pregnancy and breast feeding, in patient taking MAO-inhibitors, those with a history of drug abuse. The administration of morphine and other narcotic analgesic are also contraindicated.
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